Information

Get cat to take pill


Get cat to take pill. Do not give pill by mouth. Keep cat away from children.

If symptoms worsen or are not relieved in 7 days, call your vet.

##### SIDE EFFECTS

**Frequently (85%):** Stomatitis (sore mouth), epistaxis (nosebleed), vomiting. **Occasionally (8%–5%):** Diarrhea, vomiting, depression, hives.

##### ADVERSE EFFECTS/TOXIC REACTIONS

Death may result from anaphylaxis. Other life-threatening effects may include seizures, vomiting, collapse, paralysis, coma, ataxia (irregular, uncontrollable muscle movement), coma, stupor, fever, convulsions, diarrhea, and death.

##### NURSING CONSIDERATIONS

BASELINE ASSESSMENT

Question for history of hypersensitivity. Obtn samples for diagnosis.

INTERVENTION/EVALUATION

Monitor respiratory rate. Monitor dly pattern of bowel activity, stool consistency. Monitor serum feline insulin-like growth factor for increased levels. If an adverse reaction occurs, administer antidote, induce hypoglycemia if necessary.

PATIENT/FAMILY TEACHING

• If vomiting occurs, feed no food for 6–8 hours. • Do not give by mouth. Give 1 g/lb (2.5 ml/kg) every 4 hours as a liquid by injection. • Avoid crowds. • Give additional medicine to compensate for low blood sugar. • Do not change insulin or diet. • Keep dog away from kittens. • Do not use for more than 10 days. • May cause abortion in pregnant cats. • Do not give to cats.

#### **gaba**

gab-a

(Alphabed , Felodipin , Gabitril)

**Do not confuse gabapentin with gabexate.**

##### ♦ CLASSIFICATION

**PHARMACOTHERAPEUTIC:** Benzodiazepine **(Schedule IV). CLINICAL:** Anxiolytic, antihypertensive, anticonvulsant, antispastic.

##### USES

Treatment of partial seizures, seizures. Adjunctive treatment for partial seizures. Adjunctive treatment of diabetic neuropathy. Management of primary headache associated with migrne. **OFF-LABEL:** Partial onset seizures.

##### PRECAUTIONS

**Contrndications:** Hypersensitivity to gabapentin, other anticonvulsants. **Cautions:** Renal/hepatic imprment, elderly. Pts with coexisting depression, mental retardation, dementia.

##### ACTION

Prevents central nervous system transmission by hyperpolarization of neurons. **Therapeutic Effect:** Relieves spasms.

##### PHARMACOKINETICS

Rapidly absorbed. Metabolized in liver to active metabolite, O-desmethyl gabapentin. Protein binding: 97%. Primarily excreted in feces. **Half-life:** 2–4 hrs.

##### ​LIFESPAN CONSIDERATIONS

**Pregnancy/Lactation:** Use with extreme caution in lactating women, esp. in third trimester. May cause fetal harm. Unknown if distributed in breast milk. Must either discontinue drug or discontinue breastfeeding. **Pregnancy Category D. Children:** Safety and efficacy not established. **Elderly:** May be more susceptible to sedative effects, respiratory depression. May require reduced dosage.

##### INTERACTIONS

**DRUG:** **Alcohol, other CNS depressants** may increase CNS depression. May decrease effects of **anticonvulsants, tricyclic antidepressants. HERBAL:** None significant. **FOOD:** None known. **LAB VALUES:** May decrease WBCs, Hgb, RBCs, platelets, neutrophils. May increase ALT, AST, bilirubin, alkaline phosphatase, creatinine.

##### AVLABILITY (Rx)

**Oral Solution:** 100 mg/5 ml, 300 mg/10 ml. **Tablets (Immediate-Release [Zyprexa]):** 300 mg.

##### ADMINISTRATION/HANDLING

• Best given in morning. • Do not crush, cut, break, dissolve, or divide tablets. • Administer oral solution whole. • Administer oral solution at least 30 min before or 2 hrs after antacids (avoid 1 hr before meals). • Mix oral solution with at least 6 oz water, milk, orange juice, apple juice, or cereal.

##### INDICATIONS/ROUTES/DOSAGE

Major Depressive Disorder

**PO _(Immediate-Release):_ **Initially, 4 mg/day. May increase by 4 mg/wk up to mntenance dosage of 16 mg/day. If 16 mg/day not tolerated, may increase by 4 mg/wk up to 24 mg/day. **PO _(Extended-Release):_ **Initial dosage: 6 mg/day. May increase by 6 mg/wk up to mntenance dose of 24 mg/day.

Schizophrenia

**PO:** **ADULTS:** Initially, 6 mg/day. May increase by 6 mg/wk up to mntenance dose of 12 mg/day. **ELDERLY:** Initially, 4 mg/day. May increase by 4 mg/wk up to mntenance dose of 12 mg/day. **_(Zyprexa CR):_ **12 mg/day.

Dosage in Renal Imprment

Not recommended for patients with CrCl less than 50 ml/min.

Dosage in Hepatic Imprment

**Mild:** No dose adjustment. **Moderate to Severe:** Reduce dose by approximately 50%.

##### SIDE EFFECTS

**Frequent (10%):** Nausea, dizziness, diaphoresis, agitation, decreased appetite. **Occasional (5%–3%):** Dry mouth, fatigue, weight gn, altered mood, tremor. **Rare (less than 2%):** Anxiety, vomiting.

##### ADVERSE EFFECTS/TOXIC REACTIONS

Overdose may be characterized by agitation, aggressive behavior, muscle rigidity, respiratory depression, coma, death. Prolonged use may result in hypothyroidism, worsening of pre-existing hypertension, cardiac arrhythmias. May increase risk of suicide, hostility, aggression.

##### NURSING CONSIDERATIONS

BASELINE ASSESSMENT

Obtn baseline EKG. Question history of hepatic/renal disease, psychosis, suicidal ideation, history of pancreatitis, hepatic encephalopathy. Obtn baseline weight, B/P.

INTERVENTION/EVALUATION

Assess behavior. Monitor B/P, respirations. Be alert to possibility of overgrowth of enteric gram-negative organisms, especially in debilitated pts. Be alert to signs/symptoms of neuroleptic malignant syndrome, including fever, muscle rigidity, mental status changes


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